منابع مشابه
Calmodulin and calcium channel blockers.
IONIZED calcium regulates many cellular processes, such as cell motility, muscle contraction, axonal flow, cytoplasmic streaming, neurotransmitter release, endocytosis, andexocytosis. Intracellular Ca concentrations under steady state conditions are low, usually below 10" M. Upon stimulation, the Ca concentration increases transiently and apparently signals an appropriate response, which is oft...
متن کاملThe interaction of dihydropyridine calcium channel blockers with calmodulin and calmodulin inhibitors.
The calmodulin inhibitors R24571 and trifluoperazine were found to inhibit competitively the binding of [3H]nitrendipine to a 48,000 X g particulate fraction of rat brain with IC50 values of 1.0 and 18.8 microM, respectively. Equilibrium dialysis was used to test the ability of the dihydropyridines nitrendipine, felodipine, and nicardipine to inhibit the binding of [3H]chlorpromazine, [14C]pimo...
متن کاملThe role of calcium channel blockers in wound healing
Wound healing is a natural response to restore the injured tissue to normal. Wound healing is also complicated process involving different cellular, molecular and biochemical mechanisms and various types of cytokines and growth factors. Calcium channel blockers belong to cardiovascular medicine and administrated to treatment of hypertension, angina and cardiac arrhythmia because of vasodilatory...
متن کاملEffect of Calcium Channel Blockers on Intraocular Pressure in Rabbits
The objective of the study was to evaluate the antiglaucoma effect of calcium channel blockers diltiazem and verapamil. Albino rabbits were used and chronic glaucoma was induced in them using freshly prepared 150 units of alphachymotrypsin. 0.1 mL of drug solution was administered topically into the left eye whereas the right served as control. The pressure recording was carried out at 15, 30, ...
متن کامل61: Calcium Channel Blockers
In 1964, Albretch Fleckenstein described an inhibitory action ofverapamil and prenylamine on excitation-contraction coupling that was similar to calcium depletion. By the late 1970s, the clinical use of calcium channel blockers (CCBs) was widely accepted for variety of cardiovascular indications, including hypertension, dysrhythmias, and angina. Later indications, including Raynaud phenomenon, ...
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ژورنال
عنوان ژورنال: Hypertension
سال: 1987
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.9.3.217